Lysosomal enhancement: A CLEAR answer to cellular degradative needs

Rosiglitazone and Cardiovascular Outcomes: Is There a Clear Answer? Running title: Gerstein; Rosiglitazone & outcomes: Is there a clear answer?

Rosiglitazone and cardiovascular outcomes: is there a clear answer?

D iabetes mellitus is a common chronic disease that is characterized and defined by an elevated glucose level and that has grown in prevalence by 75% in the United States during a 20-year period ending in 2010. 1 The exact reason for this rising prevalence is not known with certainty; however, a large body of evidence implicates changes in weight, caloric consumption, reduced physical activity,...

Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin.

PURPOSE To investigate the effect of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2-E) on degradative functions of lysosomes in human retinal pigment epithelial (RPE) cells and to evaluate its mechanism of action. METHODS A2-E was coupled to low-density lipoprotein (LDL). Human RPE cell cultures were loaded with the A2-E/LDL complex, and controls were run with medium contai...

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in lysosomal enzymes, but also in some non-enzymatic lysosomal proteins, which lead to abnormal storage of macromolecular substrates. Valuable insights into lysosome functions have emerged from research into these diseases. ...

HIV/AIDS control needs a clear plan of action.

Editor – Nelson Mandela’s call for unity at the XIIIth International AIDS Conference (1) highlighted the need for all countries to combine their efforts in the fight against the HIV/AIDS epidemic, particularly in the developing world where HIV infection is mainly concentrated. Most major public health programmes implemented by the governments of developing countries have been planned or advised...